Advancement in medical treatment of congenital heart disease (CHD) has improved dramatically over the past 20 years creating a new group of children who grow up with CHD and parents who deal with challenges of the disease. Although it is clear that having a child born with CHD rapidly increases demands and stress placed on the family, little is known about the specifics of parental experience and factors determining family adaptation. In the article we review previous studies on parental well-being and mental health, caregiving demands, parent-child interactions, family functioning and satisfaction with medical care. We describe several psychosocial factors which threaten parents' well-being and promote their resilience and positive adaptation. Finally, we discuss conclusions and challenges for future researches as well as practical implications of rewieved studies.